A new study has revealed a discovery that could change the concept of human lifespan by deciphering the DNA mechanism of the longest-living mammals, the bowhead whale, which lives for more than 200 years, according to ‘Nature’ scientific journal. This protein is known as the ‘Cold-Inducible RNA-Binding Protein’ (CIRBP). After identifying this protein, scientists from the University of Rochester in New York added it to human cells and discovered that they became capable of repairing themselves with greater accuracy. In another experiment, adding the protein to fruit flies extended their lifespan.
Professor Vera Gorbunova, who led the study, said, ‘This research shows that it is possible to live longer than the current average human lifespan.’ In collaboration with scientists in Alaska, the Rochester team discovered that lower temperatures enhance the activity of the CIRBP protein. Although it is too early to determine its application to humans, Gorbunova suggested exploring ways to enhance its activity through lifestyle changes, such as cold showers or exposure to cold. Scientists emphasized that these ideas remain hypothetical at present.
DNA replication occurs during cell division, but errors in the sequence can cause mutations leading to tumors. The question of why large mammals do not get cancer at the same rate despite having numerous dividing cells is known as the ‘Peto’s Paradox.’ Bowhead whales can repair their cells better than humans, maintaining the integrity of their DNA for longer periods. The team will now test whether the protein can perform its function in smaller and shorter-lived mammals as it does in the 20-meter-long whale.
